Abstract: Co-occurrence of diabetes and hypertension is not unfamiliar in the world today and where this co-exists, it is said to aggravate cardiovascular complications. On the other hand, the significance of oxidative stress in cardiovascular condition has been recognized. Hence, this study investigated the impact hypertension and diabetes mellitus has on oxidative stress and the status of some antioxidants in non obese subjects. The study involves 204 non obese subjects who are hypertensive (NOH; n = 53), diabetes (NOD; n = 51), diabetes and hypertensive (NODH; n = 40) and non hypertensive non diabetes (NONDH; control; n = 60). There ages, blood pressure, fasting blood glucose and body mass index were determined using standard techniques while their oxidative stress and antioxidants status were analyzed via standard laboratory procedures. The results showed no significant difference in the ages and BMI in the entire groups. However, blood pressure was significant higher in the hypertensive groups while fasting blood glucose was higher in the diabetes group compared with the control. Oxidative stress was significantly higher (p<0.05) in the NOD, NOH and NODH groups compared to the control group (NONDH; 5.32±1.85). Compared to the NONDH group, vitamin A was not significantly different (p>0.05) between the groups, vitamin E was significantly higher in group NODH (13.58±5.28) and nitric oxide was significantly lower (p<0.05) in the NOH (30.87±3.48) and NODH (30.30±3.13) groups. Judging by the findings of this study, hypertension and diabetes, either existing alone or in combination have a negative impact on oxidative stress and antioxidant status.