Abstract: Some plants have been of interest to researchers in West Africa because of their use in the treatment of various disease conditions in Nigerian traditional medicine. The antioxidant activities of 24 herbal plants found in Southern Nigeria were investigated for in vitro anti-oxidant activities using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and Ferric reducing/antioxidant power (FRAP) spectrophotometric assays. Methanol extracts from Uvaria chamae root bark, Bridelia micrantha leaves, Duranta repens leaves, Harungana madagascariensis root bark and Cassytha filiformis stem gave high percentage antioxidant activities with DPPH assay model and significant (p<0.05) concentration-dependent increase in antioxidant power compared to ascorbic acid in the FRAP assay. The extracts of U. chamae root bark and B. micrantha leaves exhibited more appreciable antioxidant capacities compared to ascorbic acid at the maximal test concentration of 400 μg mL-1 in the DPPH assay. The results demonstrated that most extracts had high antioxidant effects and validate their folkloric use as remedies for different ailments. Even in the crude forms, the effects of the extracts were comparable and in some cases, higher than that of ascorbic acid, a compound with proven antioxidant activity. The findings suggest that the six plants named above with high antioxidant activities could be potential sources of novel antioxidants.