Abstract: Among all the Curcuma species, Curcumin is the most studied curcuminoid. Curcumin is renowned for its plentiful biological and pharmacological activities. Synthesis of new curcumin analogues always gained attention by scientists in the area to solve the poor bioavailability problems associated with curcumin. Uncountable analogues of curcumin have synthesized in past decades. In this review, alterations in the fundamental structure of curcumin to access associated compounds by chemical synthesis are described. We have endeavoured to sum up the biological activities of only synthetic analogues of curcumin and also most popular types of synthetic analogues of curcumin. This overview of synthetic data will provide an ease for the future scientists to develop new synthetic strategies for curcumin analogues as well as it shows the pharmacological importance and need of novel analogues.