Abstract: The opioids is useful to treat the chronic pain. Recently, the opioid mistreatment increased dramatically. The kidney damage may occur due opioid abuse treatment. The creatinine level can be measured to detect the level of kidney damage. The goal of this study is to know the effective drug to control the creatinine among opioid dependent patients. The dependent prior with Bayesian approach is applied to compare the treatment effect. The secondary data on Buprenorphine (BUP) was considered to compare the two drug treatments, viz. (1) BUP+ Standard Medical Management (SMM) and (2) BUP+Extended Medical Mangament (EMM), in opioid dependent patients. In both drug groups the mean creatinine level was found controlled over the duration of the treatment. No rapid changes of creainine level among the patients are observed. At the end of study it is found that the means of creatinine level are higher in BUP+EMM group. The Bayesian dependent prior is found to offer effective tool for drug treatment effect comparison. The drug treatment effect BUP+EMM is found to be more effective to control the creatinine among the patients.