Abstract: Eclampsia during pregnancy is often associated with a higher rate of perinatal mortality, especially in Africa. Implementation of preventive and curative strategies to reduce perinatal mortality in eclampsia needs regular assessment of risk factors. This study is held to determine the impact of several risk factors in eclampsia on perinatal mortality at Tokoin Teaching Hospital of Lomé, Togo (West Africa). It is a retrospective and comparative study concerning recorded files of 178 newborns from eclamptic women. Maternal and newborns risk factors have been compared in two groups of babies (dead ones versus still living ones: at 7th day of life). The data were processed by using SPSS 12.0 software. Chi-square Exact Test of Fisher and calculation of Odds Ratio have been used to establish significance (p<0.05) and correlation between variables. The total dead fetuses and newborns during the perinatal period was 17.4%. Vaginal rate of delivery increased significantly perinatal death, compared to cesarean section (OR = 5; p<0.001). Prematurity (gestational age less than 37 weeks) versus newborn at term was at risk of perinatal death (OR = 4.61; p<0.001). Perinatal mortality was increased in babies with lower Apgar score (<7) at first minute compared to those with Apgar score upper than 7 (OR = 2.9; p<0.001). Caesarean section in eclamptic women still prevents a lot from fetal and newborn death. Better handling of premature babies and improvement of newborn resuscitation in the center, will help to decrease perinatal mortality due to eclampsia.