Abstract: Inflammatory acute phase proteins has been identified as a possible connection between overweight, adiposity, obesity and cardiovascular disease risk, mainly in what refers to C-reactive Protein (CRP) and fibrinogen. The present study aimed to identify correlations between anthropometric and body composition measurements with these inflammatory proteins. Sample included 70 individuals aged 30-60 years which had been submitted to anthropometric and body fat mass assessment while blood samples were collected for CRP and fibrinogen determination. Very strong associations has been found between anthropometric and body composition variables. Strong associations had been found between Waist Circumference (WC), Body Mass Index (BMI), Body Fat (BF) mass and C-reactive protein in females and between C-reactive protein, waist circumference and body mass index but only in the 30-39 age group. Body mass index and waist circumference were also strongly associated with C-reactive protein in females 40 to 49 years old. Fibrinogen has shown very strong associations with body mass index and fat mass in females 30 to 39 years old and strong in what concerns to waist circumference in the same age group. Considering the well known pejorative impact of obesity, especially abdominal adiposity in what concerns to cardiovascular disease, these data has reinforced the importance of monitor inflammatory acute phase proteins like C-reactive protein in pre-obese and obese patients.