Abstract: Nematodes are important cause of reducing the body weight and producing the disease, anemia in young or debilitated animals. The aim of this study is to perform experimental research to obtain the effects of plant extraction of fumatiaceae on control of Haemonchus contortus experimentally infected goats, and its effects on weight gain and hematological parameters changes due to this parasitic infection. In Ilam province Iran where this experiment had been conducted the farmers traditionally claims that this plant could be use as a anthelmintic medicine. Twenty four draft goats, 10-12 months of age and with the average weight of 15.550 kg divided in two groups (group 1 control and the group 2 as a experimental animal infected with H. contortus (5000 L3) orally) and after 10 weeks of parasitic infection the experimental group of animals were de wormed with 6 mL kg-1 body weight fumatiaceae plant extraction. Plasma of blood sample was separated for determination of total protein, plasma total free amino acid and alkaline phosphates. At the results significant decrease in plasma total free amino acid, total plasma protein and significant increase in alkaline phosphates and acid phosphates were seen in infected group. Significant increases of body weight were observed in infected goats after 10 weeks de worming the animal with experimental fumatiaceae plant extraction. It can be concluded that fumatiaceae plant extraction could be use as a de wormer and need further investigation.