Abstract: To study the characteristics of Juvenile Rheumatoid Arthritis (JRA) in the Egyptian population, comparing it to other populations. We retrospectively studied the charts of 196 Egyptian children with Juvenile Rheumatoid Arthritis (JRA), who fulfilled the ILAR (International League Association for Rheumatology) classification of JIA and were followed up between 1990 and 2006 in the Children’s Hospital, Cairo University. Their clinical features and laboratory data were collected and statistically analyzed. The male to female ratio was 1:1.09 and the mean age of disease onset was 6.257 ±3.41 years. The mode of onset was oligoarticular in 41.3%, polyarticular in 34.7% and systemic in 24%. Chronic uveitis was found in 5.6% of the children. Antinuclear antibody (ANA) status was determined in all patients and was positive in 21.7%. Amyloidosis was present in 1.76% of patients. The spectrum of clinical presentation of the disease in Egyptian children shows both some similarities and some differences from other populations, with oligo and polyarticular onset subtypes being commonest. The cause of these differences may be due, in part, to ethnic and environmental factors. Referral bias may be another cause.