Abstract: Vitiligo is a common complex skin disorder characterized by macular depigmentation of skin, varying in size and shape caused by destruction of melanocytes. A number of environmental and genetic factors have been implicated in the etiology of vitiligo. The heterogeneity observed at clinical level needs to be evaluated for an underlying genetic heterogeneity involving autosomal and X-linked loci. Based on the clinical symptoms, vitiligo is broadly classified into non-dermatomal and dermatomal. In order to understand the various etiological/pathophysiological factors responsible for different classes of vitiligo 3551 patient’s clinical data of Indian origin was analyzed. The cases were grouped into different classes based on the lesion type at the time of disease presentation. A significant gender variation with male preponderance was observed in mucosal and acrofacial compared to other classes. 2:1 male to female ratio in clinical variants of vitiligo has been observed and has been used as a basis to hypothesize the involvement of X-linked gene(s) along with autosomal genes in the susceptibility to this polygenic condition.