Abstract: This study was designed to investigate the effects of aluminium in male Rat. The experiment was performed on four groups of male rats, with lateral ventricle cannulated. Test group received aluminium chloride in lateral ventricle. Two series received the same volume of (5.5 μL) of ACSF with pH = 3.4 and 7.2. Sham control did not receive any agent. At the end, serum FSH, LH and Testosterone in all groups were measured by RIA methods. Epididymis and vas deferense were dissected, cut, diluted and spermatozoa were counted. Data obtained were analysed by ANOVA and Tukey-test. The results were expressed as mean±SE and p<0.05 were considered significant. The results showed, FSH, LH, testosterone and spermatozoid count per gram of tissues in vas deferense and epididymis, were decreased significantly in the test group which received aluminium chloride compared with other groups (p<0.05). The results of this study indicate that toxic effect of aluminium can be exerted via central nervous system.