Abstract: The aim of this study was to determine the incidence of paraproteinaemia in patients found to be hyperproteinaemic at Komfo Anokye Teaching Hospital (KATH) and to find out the prevalence of Bence Jones Proteins (BJP) in the urine samples of such patients. The study involved 90 patients (48 males, 42 females) who reported to the Chemical Pathology Unit at KATH for protein estimation and were found to have total protein levels above 82 g L-1 using the ATAC 8000 Chemistry autoanalyzer. The initial screenings were done using serum protein electrophoresis. Serum protein electrophoresis revealed monoclonal bands in 11 (12.2%) of the patients and out of these 6.67% were found to have BJP in their urine. 57.8% had polyclonal increase in the γ region, 14.4% had hypoalbuminaemia, 6.6% gave normal electrophoretic pattern and 8.8% had either increase in α2 proteins or beta protein or beta increase with reduced albumin or decrease in all plasma proteins and a higher frequency of monoclonal gammopathy in females than in males. The study revealed a high incidence of IgG monoclonal gammopathy compared to IgA and IgM monoclonal gammopathies. There is high incidence of paraproteinaemia among hyperproteinaemic patients reporting at the Hospital. Serum protein electrophoresis should therefore, be routinely performed on all samples found to have high protein level. This will enable early treatment of patients with monoclonal gammopathies with the appropriate replacement therapy.