Abstract: This study was designed to examine selenium concentrations in patients with newly diagnosed Non-Hodgkin`s Lymphoma (NHL) and the possible association between the levels of this trace element with clinical features of the disease. Also, to test the hypothesis that selenium concentration at presentation would predict for response to treatment. This study was carried out on fifty-patients with newly diagnosed NHL and 25 control subjects, blood samples were taken for measurement of selenium by spectrometry. In comparison to the control subjects the serum selenium level was significantly lower with NHL with a mean of 0.033 (SD, 0.1) vs 0.81 (SD, 0.05), p<0.001. The mean serum selenium was significantly lower in patients with poorer performance status (p = 0.03) and in patients with advanced stage (p = 0.02), but there was no significant relation to the aggressiveness of the disease. Serum albumin was the only parameter that showed a significant positive correlation with serum selenium. There was a trend for serum selenium level to be higher in patients who achieved CR, but the difference was not statistically significant (p = 0.1). Selenium may play a role in the pathogenesis and prognosis of patients with NHL. In this study; the level of selenium was found inversely associated with the clinical stage of the disease and the performance status and may predict for the response to treatment in aggressive lymphoma. The possible utility of measuring serum selenium in NHL deserves further evaluation in clinical trials.