Abstract: To investigate the changes in plasma lipid profile, lipid peroxidation and antioxidant status in Bangladeshi pregnant women and their potential involvement in the pathophysiology of preeclampsia, we performed a case-control study consisting of randomly selected women (20-30 years) with preeclampsia (PE, n = 25) as compared to uncomplicated normal pregnant (UP, n = 22) and nonpregnant (NC, n = 25) women. The study was conducted in the Clinical Biochemistry Laboratory of Dhaka University. Serum lipid profile, thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide (LHP), Total Antioxidant Status (TAS) and vitamin C levels were measured using standard methods. Serum total cholesterol levels of PE and UP groups were significantly higher (p<0.001) compared to Nonpregnant Control (NC) group. But there was no significant difference between the total cholesterol levels of PE and UP groups. Serum TG level of PE group was significantly higher compared to UP (p<0.01) and NC (<p<0.001) groups. HDL cholesterol (HDL-C) has a lower level while LDL cholesterol (LDL-C) has a higher level in PE group compared to other two groups and these differences are also statistically significant. TBARS and LHP were significantly higher in PE group than UP and NC groups. But when compared these values between UP and NC groups, there was no significant difference. The values of TAS and serum vitamin-C levels were found to significantly decrease in PE group compared to UP and NC groups. Though there was no significant difference of TAS value between UP and NC group but vitamin-C level was significantly lower in UP group compared to NC group. Our data suggest that an abnormal lipid metabolism and particularly high triglyceride, lipid peroxides, LDL-C and low antioxidant activity and HDL-C concentrations may contribute to the promotion of oxidative stress and vascular dysfunction seen in PE and may play a significant role in its pathophysiology.