Abstract: The aim of the study was to determine surgical indication and complication of subtotal thyroidectomy in patients being treated for Graves’ disease at King Khalid University Hospital Riyadh Saudi Arabia in the period between January 1996 and December 2005. Twenty-five out of 194 adult patients with Graves’ disease had thyroidectomy for hyperthyroidism during the 10-year period representing 13% comprising 11 males and 14 females. Mean age at presentation for all the patients was 28±12 years. Males had higher serum T4 77.7±20.7 than females 49.8±21.9 pmol L-1; p<0.05. Serum T3 levels were similar in both groups 31.9±15.2 for males and 29.4±15.7 pmol L-1 for females, p = NS. Failure of antithyroid and/or radioiodine along with severe ophthalmopathy (52%), patient preference (12%) and large goiter alone (8%) were major indications for thyroidectomy in this group. Permanent remission occurred in 15 patients (60%) following the surgery. Hypothyroidism and relapse were observed in 16 (64%) and 4 (16%) of patients, respectively. One patient (4%) each experienced permanent recurrent laryngeal nerve palsy and hypoparathyroidism. It was concluded that more males than females with severe hyperthyroidism had thyroidectomy and that failure of antithyroid/radioiodine treatment and severe ophthalmopathy were the commonest indications for surgery in patients in patients with Graves’ disease while post surgical permanent hypoparathyroidism and recurrent laryngeal nerve palsy were uncommon.