Abstract: `Peppermint,` Mentha piperita is known to possess various therapeutic properties. We evaluated the anti-ulcerogenic property of an aqueous suspension of peppermint in different ulcer models in wistar albino rats. The suspension at 250 and 500 mg kg-1 body weight, orally (i.p. in Shay rat model) has significant effect in pyloric ligation induced basal gastric secretion, indomethacin and noxious chemical (80% ethanol, 0.2 M NaOH and 25% NaCl) induced gastric ulceration; showed significant protection in all models used. These findings were supported by histopathological assessment of gastric tissue and by the determination of non-protein sulfhydryl (NP-SH) contents of the stomach, as these parameters showed protection of various indices and replenishing the depleted NP-SH level by the suspension treatment, respectively. Conclusively, the ulcer protective effect of peppermint suspension may possibly be due to its anti-secretory along with antioxidative and cytoprotective through prostaglandins mediated mechanism.