Abstract: Mumps is an viral infection and most commonly refers to a systemic disease caused by the mumps virus, which is a paramyxovirus. Miscellaneous complication of the mumps have been reported. A mild leucopenia, rarely mild thrombocytopenia is the norm but to now, pancytopenia and severe neutropenia has not been reported. In this study, we reported two cases of mumps that had pancytopenia and were complicated with severe neutropenia. In addition, to look present of neutropenia in mumps, we decided to review the literature. In the both patients the outcome was infavourable and neutropenia was severe and led to sepsis and severe infections. In conclusion, these cases suggest that mumps infection should be included in the differential diagnosis of febrile neutropenia.