Abstract: To investigate the level of soluble P-Selection in Systemic Lupus Erythematosus (SLE) patients and to correlate it with disease activity and any of the laboratory data currently available. Serum levels of soluble P-selection were determined in 27 SLE patients and 10 healthy subjects, matched for age and sex, as control group. The relations between soluble P-selection and clinical and laboratory data were analysed. Mean serum concentrations of soluble P-selection were higher in SLE patients(182.34±54.64) compared to controls (103.47±32.75) with a significant positive correlation between P-selection and homocysteine. No significant correlations were found between the levels of soluble P-selection and other laboratory data and SLE Disease Activity Index (SLEDAI). Elevated serum soluble P-selection in SLE patients could indicate the presence of a continuous inflammatory stimulus in SLE and that activated platelets participate in the pathogenesis of SLE and this is important to note as it may have potential therapeutic implications with respect to use antiplatelet agents in these patients.