Abstract: The aim of present study was to compare three different endoscopic methods in the management of Type I and II gastric varices (GV): (I) gastric variceal obturation using cyanoacrylate, (II) gastric variceal sclerotherapy using absolute alcohol and (III) gastric variceal ligation by rubber (O) bands. The comparison regards the technical ease, efficacy, complications and number of sessions needed to eradicate varices. To fulfill this aim we studied 115 patients with chronic liver disease and gastric varices presented to the central endoscopy unit Ain Shams University Hospital. The patients were categorized into (3) groups: Group I included 45 patients who underwent GV obturation using cyanoacrylate, Group II included 30 patients who underwent GV sclerotherapy using alcohol injection and Group III included 40 patients who underwent GV band ligation. All patients were age and sex matched. We excluded patients with Type III GV, hepatic encephalopathy, hepatocellular carcinoma and prior history of sclerotherapy, band ligation or shunt operation. Present results showed that cyanoacrylate obturation of gastric varices was more effective in controlling gastric variceal bleeding (95.6%) than other methods with low number of sessions and low rebleeding rate than GV Ligation (35%) or alcohol injection (46.7%). So We conclude that gastric variceal obturation by cyanoacrylate proved more effective and safer than gastric variceal ligation or injection sclerotherapy using absolute alcohol in the management of Type I and II gastric varices.