Abstract: Within a 22-year period, 1983-2004, 87 cases of Acute Myocardial Infarction (AMI) were seen at the University of Maiduguri Hospital, in Northeastern Nigeria. This mainly retrospective study revealed that during this same period, the new admissions to the Medical wards of the Hospital (those presenting to the hospital for the first time) totaled 25,588 patients. Myocardial infarction thus formed 0.34% of all new admissions over the period under review. The age-range of the affected patients fell between 38 and 67 years, with the 41-50 year age group mostly affected. Mortality was 39% among the cases seen. Male to Female ratio was 7.5:1. Forty-one percent of the affected patients were both hypertensive and diabetic, while 55% had hypertension alone. The commonest complications were congestive cardiac failure due to severe pump failure, arrhythmias, mitral regurgitation and pericardial effusion. The commonest site of the infarction was the anterior myocardium. About 36% of the total number of cases presented in the last 4 years of the study period. The presence of myocardial infarction in the far Northeastern Nigeria is established and the incidence of this disease, though lower than that of other parts of Nigeria, is rising.