Abstract: The purpose of this study was to determine the effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) therapy, Low Energy Laser (LEL) therapy and combine therapy (TENS and LEL) on pain and functional performance of patients with shoulder pain. Fortyfive individuals with shoulder pain have participated in this study. Subjects were randomly divided into 3 groups and were assessed before and after a 3 week therapy phase. Groups were re-assessed for control one month later. Pain intensity was scored on a Visual Analogue Scale (VAS). Range of Motion (ROM) was measured with goniometer. Constant’s shoulder index was applied for functional assessment. First group performed TENS, second group performed LEL and third group performed combine therapy (TENS and LEL). Statistically significant differences were found before and after therapy for ROM, VAS and functional performance in all three groups. When the three groups were compared, ROM, VAS and functional performance test results were found to be significantly better in the combine group than the other groups after the therapy. The results of this study suggested that when LEL and TENS were used combined in shoulder pain treatment, they can improve ROM and functional performance and reduce pain better than when they are applied separately.