Abstract: The methanolic and aqueous extracts of E. fluctuans was evaluated in experimental diarrhoea, induced by castor oil in mice. Both methanolic and aqueous extracts, given orally at the dose, of 250 mg kg-1 body weight, showed significant anti-diarrhoeal activity as compared to that of the control. Both the extracts at the above dose levels also significantly reduced the intestinal transit of charcoal meal in mice. The in vitro antimicrobial activity of the extracts showed variable result. The methanolic extract moderately inhibited the growth of Shigella dysenteriae, Shigella boydii and Shigella flexneri, while the aqueous extract inhibited the growth of Staphylococcus aureus, S. dysenteriae and S. boydii. But both the methanolic and aqueous extracts did not show any significant effect on Escherichia coli and Pseudomonas aerugenosa. All the results indicated that the extract of E. fluctuans possesses anti-diarrhoeal activity.