Abstract: In the present study endocervical swabs from women classified in three groups were taken. The groups were women who had been on intra-uterine contraceptive devices for at least two months and experiencing vaginal discharge noticed visibly or through the use of speculum (n=16); first control subjects which were women who had been on intra-uterine contraceptive devices for at least two months but not experiencing vaginal discharges (n=14) and a second control subjects which were women who had never been on contraception (n=2). Candida albicans, Neisseria gonorrhea, Klebsiella species and Escherichia coli were pathogens isolated within the experimental group (n=16). Lactobacilli and Candida albicans were isolated in the first control subjects (n=14). No microbial growth was observed within subjects of the second control group (n=2). Statistical analysis indicated that only 25% of the experimental subjects showed evidence of infection while 14.3% of women within the first control subjects (n=14) were infected. Since the establishment that infection occurring in less than one month of intra-uterine contraceptive device implant can be meaningfully ascribed to the presence of the intra-uterine contraceptive device, it is recommended that cases of women implanted with intra-uterine contraceptive devices, experiencing vaginal discharges and irritation should be thoroughly investigated before prescription of drugs by physicians.