Abstract: The present study aims to compare the effects of two compounds 4-(2-phenyl-1,2,3-triazole)-3, 5-ethoxycarbonyl-2, 6-dimethyl-1,4-dihydropyridine (DHP) and 4-(2-phenyl-1,2,3-triazole)-3,5-diethoxycarbonyl-2,6-dimethylpyridine (PY) on rabbits. Both found to be good activators of MAO-B. The activation using PY was increased by combination with vitamin E. Also, the effects of DHP and PY on rabbits including liver RNA and DNA content as well as serum clinical analysis were investigated. The obtained results showed a decrease in RNA content while showed an increase in the DNA content to the level of 68 and 124%, respectively.