Abstract: In this study total bilirubin, albumin and electrolytes levels in HIV positive persons were determined followed by anion gap calculation. This is with a view to generating the non-existent baseline data that could aid in monitoring the progression of AIDS in resource limited settings like ours. Results of the various analysis showed that the concentrations of the conjugated, mean total and unconjugated bilirubin in HIV positive persons ranged from 0.50 to 1.3, 1.07 to 2.10 and 0.01 to 1.50 mg/100 mL, respectively while those for the control subjects, (HIV non-infected) were from 0.50 to 1.66, 0.80 to 1.60 and 0.10 to 0.70 mg/100 mL, respectively. Also while the mean total and unconjugated bilirubin concentrations were higher in HIV positive persons than in the non-infected, the reverse was found to be the case for albumin levels. The albumin levels of HIV positive persons ranged from 29 to 37 g L-1 and for the uninfected it was from 34 to 39 g L-1. The results of the electrolyte determination revealed that the mean concentrations of the electrolytes in HIV positive persons were 99.3 mmol L-1 (Cl-), 18.08 mmol L-1 (HCO3-), 132.4. mmol L-1 (Na+) and 3.3 mmol L-1 for K+. For the uninfected the mean values recorded included 100 mmol L-1 (Cl-), 20.3 mmol L-1 (HCO3-), 137.4 mmol L-1 (Na+) and 4.08 mmol L-1 (K+). The results of the electrolytes determination are all within normal range though there were slight decreases in the HIV (+) persons. The anion gap values overlapped between the infected and the non-infected.