Abstract: The study was conducted to analyzed plasma/serum of azo-ospermic, oligospermic and asthenospermic men for metabolic, renal and hepatic functions to observe the relationship between fertile and infertile states. Simple and valid tests such as biochemical analysis for sugar (metabolic test), urea and creatinine (renal function test) and serum glutamate pyruvate transaminase (SGPT) and serum bilirubin (hepatic function test) were performed employing commercially available reagents (kits) and spectrophotometer. Four groups of patients, including an azoospermic, oligospermic, asthenospermic and normospermic group, were examined for the said purpose. The results suggested that there was no remarkable difference in various physiological functions between the fertile and infertile states.