Abstract: A group of horseradish peroxidase-conjugated lectins (Con-A, WGA, PNA, RCA-I, SBA, DBA, UEA-I) and the classical histochemical techniques to detect sialic acids were used to study the content and distribution of terminal sugar residues of glyco conjugated in the skin-mucosa transition zone in the nasal septum of healthy patients. This transition zone possesses a specific histological characteristic, where is changed a stratified epithelium first into a columnar and then into a pseudostratified one. The results showed a histochemical pattern in the basal cells of the epithelium similar to the common pattern in the epidermis, but different to the basal cells of the nasal mucosa. The transition zone possesses terminal residues rich in Nac-Glucosamine, neuroaminic acid, dimer Gal (1-3)-GalNac and N-acGlc and D-Glc/ D-Man.