Abstract: The research work was conducted to find out the differences in the serum of Cu, Fe, Zn and serum proteins in children of different degrees of malnutrition as a result of some disease. For this purpose a total of 100 children of pre-schooling age (0-4 years) having 85 malnourished and 15 apparently healthy were selected. Results revealed that diarrhoea, fever and malnutrition were the major diseases/ailments. Malnutrition was more prevalent in children of 12 and < 12 months of age, in males and in children of low socioeconomic status. All types of milk were more frequently offered to males and breast feeding was more frequently offered by mothers of uneducated class and undermatric. Levels of serum copper (Cu) and iron (Fe) were significantly (P<0.05) higher in malnourished children. Serum total proteins and globulins were significantly (P<0.05) lower in malnourished children of first degree in low socioeconomic group.