Abstract: Background and Objective: Black Band Disease (BBD) causing tissue loss and mortality has come out as a serious threat to coral reefs. This disease has been reported from several coastal regions in the world, however little is known the procedures for controlling infectious diseases of this corals. The purposes of this study were to screen and characterize of coral-associated bacteria having antipathogenic potency against BBD coral disease. Materials and Methods: One hundred and eighty three healthy coral derived bacterial isolates were screened. Thirty four strains were selected for their ability to inhibit BBD pathogenic isolates. The disc-diffusion method were used to rescreen for their antipathogenic property against BBD pathogenic isolates. Then, the 16S rDNA approach and microbiological characteristics were used to identify bacterial selected. Results: Thirty four (18.58%) strains showed their ability to inhibit the growth of BBD pathogenic isolates. The NM1.2, NM1.8 and NM1.9 isolates were selected according to their consistency of BBD inhibition. The DNA sequences analyses showed these isolates belonged to only one major groups of γ-proteobacteria. The NM1.2, NM1.8 and NM1.9 isolates were all closely related to genus Pseudoalteromonas. Conclusion: Even though the low diversity of bacterial phylotypes were present within the coral family Acroporidae, however, this study provides the first evidence of acroporid coral bacteria possessing antipathogenic activity against BBD coral disease that can be recovered from corals. The sequence data of these antipathogenic strains, Pseudoalteromonas flavipulchra strain NM1.2, Pseudoalteromonas maricaloris strain NM1.8 and Pseudoalteromonas piscicida strain NM1.9, in this study have been deposited to the GenBank data library under the accession number LC184593, LC184594 and LC184595.