Abstract: Industries are major sources of pollution in all environments. Based on the type of industry, various kinds of pollutants can be discharged directly or indirectly into the environment. In this study, effluent discharge from brewery were collected and compared with values recorded for its receiving stream. Parameters investigated included Total Suspended Solids (TDS), Biological Oxygen Demand (BOD5), Chemical Oxygen Demand (COD), total ammonia, nitrates and phosphates. ANOVA and Dunnet’s Multiple Test were used for the analyses of these parameters. Besides, microbial parameters in the form of total/faecal coliform, total viable count, faecal enterococci, E. coli and Salmonella, were sampled and analysed using the Most Probable Number (MPN) method. With the exception of the pH, all the parameters measured from the brewery effluent site as well as in the river indicated higher levels than those permitted by the GSA and WHO. The study revealed that effluent from the waste treatment plant from the brewery was technically efficient with respect to most of the physicochemical parameters. This could, however, not be said for their microbial counterpart as levels of biological indicators of pollution all exceed the WHO and GEPA recommendations. It is, therefore, being recommended that the brewery authorities as well as the EPA of Ghana must ensure that the brewery effluents meet quality standards. This action is urgently warranted as high level pollution of the industrial effluents cause’s environmental problems which will affect plant, animal and human life.