Abstract: Heavy metal contamination has accelerated due to the rapid industrialization world wide. Accumulation of metals in excess can modify the structure of essential protein or can replace an essential element. Aim of this study is to check the Mesorhizobium species for their tolerance towards multiple metals as well as antibiotics and further check whether these metal resistant microbes are producing any plant growth promoting substances. Mesorhizobium strains were isolated from the nodules of chickpea, were tested for their tolerance to both heavy metals and antibiotics by agar plate dilution method and by the disc diffusion method respectively. Plant growth promoting activity was checked by the standard methods. All of the isolates showed tolerance to cadmium, chromium, nickel, lead, zinc and copper. All the isolates showed maximum tolerance towards lead and zinc which was followed by nickel and chromium. Mesorhizobium species also showed tolerance towards antibiotics, 70% of the isolates were tolerant to nalidixic acid, 60% were tolerant to each tetracycline and nitrofurantoin whereas no isolate was found to be resistant towards cloxacillin, ciprofloxacin and chloramphenicol. Mesorhizobium strains were also tested for their Plant Growth Promoting (PGP) substances, all the isolates produced good amount of indole acetic acid and were positive for ammonia and Hydrogen Cyanide (HCN) but only three isolates (RC1, RC3 and RC4) produced siderophore on the plates as well as in the liquid culture. In conclusion Mesorhizobium strains can be used for the growth promotion, as well for the detoxification of the heavy metals in metal polluted soils.