Abstract: A total of 60 samples of smoked fish (Clupea harengus) were purchased randomly during summer of 2010 from Port-Said markets. The samples were examined for the levels of ochratoxin A and aflatoxin B1 and the contents of moisture and sodium chloride. The obtained results revealed that the mean values of ochratoxin A and aflatoxin B1 levels in the examined smoked fish were 0.73±0.22 and 4.66±0.94 ppb, respectively. While the contents of moisture and sodium chloride (on dry basis) in the examined samples were 66.07±0.27 and 7.36±0.08%, respectively. On the assessment of the toxin levels, ochratoxin A and aflatoxin B1 were not detected in 80% (48) and 68.33% (41) of the examined smoked fish samples, respectively. On the other hand the contents of moisture and sodium chloride (on dry basis) in the examined samples were ranged from 61.83 to 70.98% and from 6.14 to 8.34%, respectively. From the sum of the examined smoked fish samples, 20% (12) and 31.67% (19) were exceeded the permissible limits for ochratoxin A and aflatoxin B1, respectively. The relationship between the levels of ochratoxin A and aflatoxin B1 and the contents of moisture and sodium chloride as well as the public health significance of these toxins were discussed.