Abstract: This study was conducted for one year period during March 2008 to February 2009 in the Eastern Province of Saudi Arabia. Out of a total 250 samples collected during this period 178 (71.54%) were found positive. The dermatophytes causing different types Tinea were Epidermatophyton floccossum, Microsporum canis, M. gypseum, Trihophyton mentagrophytes, T. rubrum, T. schoelneinii, T. soudanense, T. violaceum and T. verrucossum. Besides these non-dermatophytes fungi Candida albicans, C. krusei, C. tropicalis and Fusarium solani were also isolated causing infection at different sites of human body. Samples from females yielded higher percentage of dermatophytes as compared to males. The percentage of infection of T. capitis and T. corporis were found to be higher in the age group of 0-15 years, while, T. pedis and T. cruris dominates in the age group of 16-30 years. Orychomycosis was dominated among the age group of 31-45 followed by 46-60 years. While, above 60 years yielded very low percentage of dermatophytes. Present study showed that more females were affected by dermatophytes (almost double in number) than males. Result of present study clearly indicates that the epidemiology of dermatophytes significantly differs from other regions of Saudi Arabia.