Abstract: Background and Objective: Vibrios are ubiquitous in environmentally polluted seawater with special reference to municipal sewage. In the current study, four main species of Vibrios had been frequently isolated/identified from the Common Pandora fish (Pagellus erythrinus) collected through summer 2014 to spring 2015. Materials and Methods: A panel of specific morpho-chemical conventional and semi-automated tests (API 20E) were used to uncover the identities of the retrieved isolates. The degree of similarity within API 20E identification charts as well as the taxonomical matching against standard criteria stated at the Bergey's Manual of Systematic Bacteriology were concomitantly used for final confirmation of the retrieved isolates. Statistical analysis was done by two-way ANOVA using SPSS. Results: The four fully confirmed species were Vibrio vulnificus (V. vulnificus), Vibrio parahaemolytices (V. parahaemolyticus), Vibrio fluviales (V. fluviales) and Vibrio alginolyticus (V. alginolyticus). The research has revealed that V. fluviales was the highest isolated species (33.33%) in Summer 2014 and Spring 2015 (27.77%), while V. vulnificus was the lowest isolated through summer 2014 (4.44%) and spring 2015 (5.55%). In winter season 2014, V. parahaemolyticus presented the highest percentage of infection (20%), while V. alginolyticus was associated with the lowest percentage of infection (2.22%). Antibiogram has revealed that most of the retrieved V. alginolyticus and V. parahaemolyticus were sensitive to doxycyclin, polymyxin and resistant to oxytetracyclin, florfenicol and ampicillin. However, V. fluviales isolate were sensitive to all tested antibiotics with the exception of ampicillin. Interestingly V. vulnificus were sensitive to doxycyclin, polymyxin, oxytetracyclin, while resistant to florfenicol, sulfamethoxzole-trimethoprim and ampicillin, which was remarkably different from the antibiogram recorded for other retrieved Vibrio species. Conclusion: Conclusively, the achieved results throughout the current study were indicative of a consistently growing municipal sewage pollution across the western coasts of Tripoli, Libya.