Abstract: Dolphins are one of the most iconic species of the marine world. With their playful nature and high intelligence, dolphins have enthralled the hearts of people of all ages from all over the world. The worldwide distribution of dolphins through the diverse global aquatic environments has gifted them with global popularity compared to other aquatic animals in direct contact with the human communities. In the past few decades, deaths, injuries, toxicities, genetic disorders and overfishing were continuously increasing due to faulty anthropogenic activities in th marine environment. The increasing global threats to dolphins’ populations have remarkably enhanced the public awareness about these threats and triggered scientific communities to configure reliable/effective solutions. Combating trans-species infectious diseases and development of reliable, safe and cheaper diagnostic as well as therapeutic tools for tissue alterations were the infrastructure of dolphins’ veterinary research through the past few decades. However, the veterinary library is suffering from remarkable scarcity of comprehensive literatures about diseases/disorders affecting different body systems of marine mammals. Thus, we present the current review in trial to shed the light on the most common affections of dolphins as a model of the most critically impacted marine mammals.