Abstract: Aim of the present study was planned to assess the biodiversity of the marine environment around the Muttom coastal region and then to isolate and characterized the secondary metabolites from the eleven sponges and screen them for their mosquito larvicidal effect. Due to increasing resistance of the vectors mosquitoes causing diseases of importance in public health, to chemical insecticides, is necessary the searching for alternative control methods, as the use of marine sponges extracts with insecticide activity, owing to its capacity of biodegradation and generation of minor environmental damage. In this work the insecticide activity is evaluated for the mixture of chloroform with methanol extracts of the eleven marine sponges on stadium V instar larvae of Aedes aegypti (L.) and Culex quinquefasciatus (L.) in conditions of laboratory (25°C and 75% Relative Humidity). The sponge extracts of Clathria gorgonoids and Callyspongia diffusa was found to be the most effective against A. aegypti larvae showed LC50 values at <50 ppm. A result demonstrates that Ircinia campana extract is most active against two insects, as long as the extract of Sigmadocia carnosa has a higher toxic effect on Aedes aegypti than on Culex quinquefasciatus. Between the sponges Clathria gorgonoids and Callyspongia diffusa were found to be more active towards both larvicidal and insecticidal properties. In view of both these activities, the subsequent sponges Haliclona pigmentifera, Sigmadocia carnosa, Petrosia similes and Ircinia fusca could be used to obtain novel pesticidal molecules.