Abstract: The aim of this study was the evaluation of the immunostimulatory effects of alginic acid and anti-streptococcus vaccine on the Growth Rate (GR), Specific Growth Rate (SGR), Feed Conversion Ratio (FCR), Condition Factor (KF) and Survival Rate (SR%). The weight range of fish were 5-8 g and the trials were divided to 4 treatments with triplicate groups including control, vaccine, vaccine+alginic acid and alginic acid and each treatment included 3000 fishes. The period of this study was 4 month and biometry was done 6 times (every 20 days intervals) at the end of experimental period the blood samples were taken from all treatments and hematological parameters were evaluated. The results showed that GR had a significant increase in vaccine+alginic acid treatment when compared with the control group (p<0.05). SR% showed a significant increase in vaccine+alginic acid and alginic acid treatment in compared with control group (p<0.05). Significant elevation in the percentage of lymphocyte observed in vaccine, vaccine+alginic acid and alginic acid treatment when compared with control group have observed. According to the results, it seems that prescription of vaccine and alginic acid were stimulated lymphocyte proliferation in all treated groups and therefore fish resistance increase to environmental stress and pathogen.