Abstract: The effects of different concentrations of cassava effluent on eggs and larvae of Clarias gariepinus were evaluated in this study. Based on the range finding test, five concentrations of the effluent 0% (control), 2, 4, 6 and 8% were tested. There was significant difference (p< 0.05) in the percentage fertlisation of C. gariepinus eggs subjected to the various treatments. The higher concentrations of cassava effluents, 8, 6 and 4% were very toxic, less than 20% hatching success. The hatching percentage was inversely proportional to the effluent concentration (from 90.00±1.0% in the control to 16.00±1.5% in 8% cassava effluent concentration). Hatching started (22.0±1.0) hours after fertilization in control media (0% concentration) and lasted for 24.5±0.1 h while hatching began at 23.0±0.5 and 24.5±0.5 h in the 2 and 8% concentrations. There was significant (p< 0.05) difference in MT50 in all the tested concentrations. The MT100 were not similar (p< 0.05) in all the tested concentrations of effluents. Based on the result of this study, cassava effluents adversely affected fish reproductive performance and larvae survival. Therefore, cassava effluents should be diverted away from pond waters.