Abstract: The general health problems of detergents with emphasis on the weight, hematology and histopathology were investigated by ingesting 20 mice (about 30 days old) with detergent solutions. The mice were grouped into five sets, comprising of five mice each. The control group (group 1) was given ordinary water while groups 2-5 were given 25, 50, 75 and 100% v/v of the detergent solutions, respectively as the only sources of water. The mice had access to feed (F.A Feeds, Lagos) ad libitum in suspended, meshed-bottom cages for about 4 weeks. The Relative Growth Rate (RGR) in percentage of the control mice was 7.1 while the RGR of the mice exposed to 25, 50, 75 and 100% v/v of the detergent solutions were -33.2, -43.9, -52.5 and -59.3, respectively. A significant difference (p<0.05) exists between the mean weight of the control mice and the mean weights of the mice placed on the different concentrations of the detergent. The hematology analysis of the exposed mice showed marked reduction in the packed cell volume, hemoglobin, white blood cells, red blood cells and total protein. Furthermore, the blood of the exposed mice had dose-dependent hypochromasia, macrocytosis, microcytosis, eosinophilia and arisocytosis. A significant difference (p<0.05) also exists between the mean blood parameters of the control mice and the mean blood parameters of the mice exposed to the various concentrations of the detergent. The internal organs (heart, kidney, liver and reproductive organs) of the exposed mice showed marked histological changes compared to the control mice and the extent of the injuries increased with the concentrations of the detergent solutions. The results of the research highlight health hazards of detergent exposure and underscore the needs for proper handling and disposal of detergents.