Abstract: A study was conducted with the objectives to determine the resistance of maize varieties to maize weevil, Sitophilus zeamais. It was conducted at Jimma University College of Agriculture and Veterinary Medicine in entomology laboratory at room temperature of 25-27°C and 40-60% RH in 2011/2012. The maize varieties were collected from Bako and Holeta Agricultural Research Centers, Ethiopia and local market, Jimma-Merkato. A total of 13 maize varieties were screened for their relative resistance to S. zeamais. Dobie index of susceptibility was used to classify the varieties in to different reaction categories. The varieties were significantly different in terms of susceptibility index. Only one variety, ‘BHQP-542’, had 3.5 index of susceptibility and was regarded as resistant variety to maize weevil attack. However, most of the varieties, namely BH660, BH670, BH543, BHQPY545, Gibe-1, Gibe-2, Wanchi, Argane, Hora and Local variety-Orome, had index of susceptibility 4.6, 5.3, 4.7, 4.8, 4.9, 4.8, 5.2, 5.7, 5.2, 6.0, respectively and are regarded as moderately resistant to maize weevil attack. Two varieties (BH661 and Kuleni) had index of susceptibility 7.11 and 7.09, respectively and are regarded as moderately susceptible varieties to maize weevil attack. The resistant variety produced low numbers of F1 progenies (51.33), had a high median developmental time (48.33 days), a low percentage of seed damage (15.85%), less production of grain dust (powder (0.03%)), low percentage of seed weight loss (4.11%) and high percent weevils mortality (14.24%) and seed germination (93.66 (undamaged) and 86.60% (damaged)). Weevil progenies emergency is significantly and positively associated with seed damage and weight loss but inversely with median development time. The use of resistant varieties in insect pest management is an eco-friendly and cost effective means that should be promoted for S. zeamais management in maize especially for small-scale farmers in the tropics.