Abstract: Laboratory experiments were conducted at the University of Ghana, Legon, to determine the extent of damage and weight loss caused by Prostephanus truncatus to dry chips of varieties of cassava (biafra, bosomensia), yam (pona, takyeman), cocoyam (mankanipa (red), mankaniserwa (white) and plantain (apantu, asamienu) grown in Ghana and kept over 3 separate storage durations of 30, 60 and 90 days. Data on insect preferences for the various dried chips as well as the susceptibility of the substrates; number of adults produced, weight of adults that developed on them, weight loss of the chips and the weight of frass produced from insect feeding over the 30, 60 and 90 days exposure periods were recorded. The beetles exhibited higher levels of preference for cassava (biafra and bosomnsia) and plantain varieties (apantu and asamienu), compared to the cocoyam (white and red) and yam (pona and takyeman) varieties. Also significantly more P. truncatus (p<0.05) survived and bred on the cassava (biafra and bosomnsia) and plantain (asamienu, apantu) varieties, than yam (pona, takyeman) and cocoyam (red, white). Also, the mean weight of adults recorded on the chips of plantain (apantu, asamienu), cassava (biafra, bosomnsia), cocoyam (red and white) were heavier than those recorded on yam (pona and takyeman). Furthermore, the results showed that the amount of frass produced and percentage weight loss recorded due to the activity of P. truncatus increased with time over 3 months exposure period. More losses were also recorded on the cassava and plantain than the yam and cocoyam chips.