Abstract: Acaricidal activities of Ivomec (Ivermectin) and Dectomax (Doramectin) were evaluated in camels infested with sarcoptic mange mites. The activity of Dectomax was stronger and last longer than Ivomec as it reduced the number of mites on the tested animals four weeks after treatment. The Ivomec (1% ivermectin) dose of 0.2 mg kg-1 on body weight basis is not effective in killing the mite infestation in a short period of time. Whereas, the Dectomax (1% dormaectin) dose of 0.2 mg kg-1 on body weight basis killed all the mite infestation quickly and was effective for a longer period of time. The acaricidal efficacy of Ivomec (Ivermectin) was less than Dectomax (Doramectin) (p<0.05) on sarcoptic mange mites (Sarcoptes spp.) of Camels (Camelus dromedarius) under the climatic conditions of Al-Ahsa, Saudi Arabia. The mean values of glucose, urea, creatine, creatinine, GOT and GPT in the serum increased in camels treated with Dectomax (p>0.05 ) than those treated with Ivomec . The GOT values in the serum of camels treated with Dectomax were higher (p>0.05) than the normal or Ivomec treated animals. In conclusion, this endectocide might have affected the normal functions of liver or other organs of camels. Further studies on the use of endectocides for controlling all the parasitic helminthes and arthropods in Saudi camels are strongly recommended covering all the seasons in a year.