Abstract: This study was conducted to evaluate, the more efficient insecticide, between three bio-insecticides used, in a chemical control of spiny bollworm and to compare a purely chemical control, with an integrated control of cotton boll worms, which was already studied by the same authors. Cotton variety vermin planted in a Complete Randomized Block Design (CRBD), with 6 treatments and 5 replications. The treatments were as follows: three concentrations of spinosad, 200,4000 and 10000 ppm, Neem-Azal, 50 ppm, Bt., 3000 ppm and control. Insecticides were sprayed, with an interval of 15 days. For sampling, 10 plants were chosen randomly and weight and number of attacked, or healthy blossomed or blind bolls measured. Results of analysis of variance by MSTAT-C showed that, there is a significantly difference, between use of 200 ppm and use of each of 10000 and 4000 ppm of Spinosad. Between the treatments, those sprayed with 4000 and 10000 ppm of Spinosad had the lowest number of damaged bolls, the plots sprayed with 200 ppm Spinosad had the minimum number of blind damaged bolls, followed by plots, in which Neem-Azal and Bt., were sprayed.