Abstract: This study evaluated multiple applications of spinosad at three application rates, emamectin benzoate, Beauveria bassiana, azadirachtin and different Bacillus thuringiensis delta endotoxins for controlling diamondback moth populations, Plutella xylostella (L.), on three commercial collard (Brassica oleracea var. acephala de Condolle) farms in South Carolina. Spinosad and emamectin benzoate were the most efficacious at consistently providing excellent control of diamondback moth populations. Azadirachtin, B. bassiana and B. thuringiensis delta endotoxins may be useful early in collard growth to control low populations of diamondback moth, but were not consistently effective at maintaining diamondback moth populations below the economic threshold in the later stages of field trials, especially when diamondback moth larvae averaged more than three per plant.