Abstract: Flunixin meglumine, ketoprofen and phenylbutazone were classified with the group of compounds commonly referred to as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). The purpose of this study was to evaluate the brain, renal and hepatic effects of 3 NSAIDs (flunixin meglumine, ketoprofen and phenylbutazone) when administered IV to clinically normal Iranian cross-breed goats. The experiments were conducted on twenty clinically normal adult male goats. Goats were randomly assigned to 4 groups: saline (n = 5), flunixin meglumine (n = 5) ketoprofen (n = 5) and phenylbutazone (n = 5). Drug administration was initiated at 8 AM on day 1 and continued every 12 h for 12 days. Flunixin meglumine, ketoprofen and phenylbutazone were administered at the dose rate of 2.2, 2.2 and 4.4 mg kg-1, respectively. Daily blood and urine samples were collected from all goats for hematology, enzyme activities and urinalysis. Immediately after euthanasia, complete necropsy was performed on all goats and gross lesions were recorded. Clinically, mild anorexia and diarrhea were observed during the study only in phenylbutazone treated group. Mean total and differential of leukocytes, RBC and PCV did not changed significantly. Serum biochemical analysis indicated a significant treatment effect on urea nitrogen, creatinine and enzyme activities. Treatment effect was not significantly evident in results of urinalysis. Macroscopic and microscopic findings. Considering brain, renal and hepatic lesions, the toxic potential of the NSAIDs, when use of these compounds is contemplated in clinical cases, the risk of adverse effects and the comparative toxic potential should be considered, along with the efficacy of the compound for the condition being treated.