Abstract: The study was conducted to determine the relative resistance of Red Sokoto and Sahelian goats to experimental infection with infective larva (L3) of Haemonchus contortus. At the age of about 7-9 months weaned goats were transferred to individual feeding pens and fed concentrate at 08:00 h and given Digitaria smutsii hay ad libitum. Fifteen goats of each breed were divided into 3 groups of five animals each. Goats were either given 0 L3 kg-1 (treatment 1), 75 L3 kg-1 (treatment 2) or 100 L3 kg-1 (treatment 3), three times weekly for 3 weeks. The faecal egg count expressed in Eggs per Gram (EPG) was significantly higher (p < 0.05) for the Sahelian (1477±153.4) than the Red Sokoto (607±147.5). The PCV didn`t show any significant difference between breed however the difference between treatment was significant at p < 0.05. The average daily gain was higher for the Red Sokoto (11.2 g day-1) than the Sahelian (5.6 g day-1) even though the difference was not significant (p > 0.05). The mean total protein was statistically different between breeds. The Red Sokoto had higher (p < 0.05) than the Sahelian (64.6 ± 1.81 vs 57.6 ± 1.86). The mean albumin and globulin concentration did not differ significantly between breed. It was concluded that the Red Sokoto were relatively more resistant to Haemonchus contortus on the basis of faecal egg count, weight gains, changes in the PCV and total serum protein concentration.