Abstract: This study was aimed at determining the phytochemistry and antimicrobial properties of the methanolic extract of Baissea axillaris leaf. Phytochemical analyses of B. axillaris leaf using procedures described by Trease and Evans, revealed the presence of saponins, phenolic compounds, eugenol oil, glycosides and tannins. Methanolic extract of the leaf showed antimicrobial activities against some organisms. The extract was most active against Staphylococcus aureus yielding the highest zone of inhibition (15 mm) as well as the least minimum inhibition concentration of 125 μg mL-1. It was least effective against Escherichia coli as minimum inhibition concentration was above 500 μg mL-1.