Abstract: The antimicrobial activities of the acetone, methanol and water extracts from the leaves, stems and roots of this herb were investigated against 10 bacterial and 5 fungal species using the dilution method on solid agar medium. The acetone extracts from the leaf and root were active against Gram-positive bacteria with Minimum Inhibitory Concentration (MIC) ranging between 1.0 and 7.0 mg mL-1, whereas the acetone stem extract was able to inhibit all the bacterial strains at 0.5-7.0 mg mL-1. The methanol extracts of the 3 plant parts showed activity against all the bacterial isolates with MIC values ranging between 0.1 and 10.0 mg mL-1. Again all the extracts exhibited appreciable activity against all the fungi species investigated. The methanol extract of the root showed 100% inhibition against Aspergillus niger, A. flavus and Penicilium notatum at 5 mg mL-1 while it was 88.61% inhibition in Mucor hiemalis. The ability of the extracts of F. muricata to inhibit the growth of several bacteria and fungi is an indication of its broad-spectrum antimicrobial potential which may be employed in the management of bacterial and fungal infections.