Abstract: Faecal samples of domestic animals and poultry were subjected to survey frequency of occurrence of pathogenic Campylobacter spp. in India (Pune) and Iran (Shiraz). Antimicrobial susceptibility of the isolates was assessed to evaluate the rate of antibiotic resistant campylobacters in both of the areas. The methods for isolation of pathogenic Campylobacter spp. was Kapadnis Baseri (pret- KB) and for antimicrobial susceptibility of the isolates was disc diffusion and E- tests. A total 70 and 37 Campylobacter spp. were isolated in India and Iran respectively. All pathogenic Campylobacter spp. isolates were sensitive to ciprofloxacin, however, varied responses to the other antibiotics have been observed among the isolates. In addition, lowest MIC values were found for ciprofloxacin and highest MIC values were found for Ampicillin and Choloramphenicol. Overall, based on our observations domestic animals and poultry should be considered as reservoirs of Campylobacter spp. in both of the countries. Although, frequency of existence of antibiotic resistance Campylobacter in India was relatively high, ciprofloxacin resistant Campylobacter were isolated neither from India nor Iran.