Abstract: The antimicrobial spectrum of quinolones namely ceporex, ciprofloxacin, tarivid, peflacine and nalidixic acid on Staphylococcus aureus isolated from hospital patients in Okigwe was studied. Out of 79 samples examined Staphylococcus aureus was isolated from 50(71.42%). Out of 17 urethral swab isolates 15(88.27%), 10(58.8%), 12(70.5%), 8(47.05%) and 8(47.05%) were resistant to ceporex, ciprofloxacin, tarivid, peflacine and nalidixic acid, respectively. The percentage of the of the S. aureus isolates resistant to each quinolone was 62, 64, 74, 44 and 88% for ceporex, ciprofloxacin tarivid, peflacine and nalidixic acid, respectively. Isolates from urine, semen and vagina were less resistant to the quinolones.