Abstract: In this study, the effect of the methanolic extract of the stem bark of Entandrophragma angolense on gastric mucus secretion, gastric mucus cell count, malonialdehyde concentration were investigated in albino rats. Two doses of the extract (100 and 200 mg kg-1) significantly increased gastric mucus secretion in the pre-treated animals (p< 0.05). Similarly, the reduction in gastric mucus secretion was found to be statistically significant at a dose of 400 mg kg-1 (p< 0.05). Entandrophragma angolense extract also increased gastric mucus cell count significantly in animals pre-treated with low dose (p< 0.05). These results indicate that the mechanism of antiulcer activity of the extract may be due to increase gastric mucus secretion which is mediated via increased gastric mucus cell counts and activity of the gastric mucus cells.